BIO-698 / 2 crédits

Enseignant: Clerc Roger G.

Langue: Anglais

Remark: Next time: Fall 2024


Frequency

Every year

Summary

To expose participants to translational biomedical research (from bench to bedside and back) and drug discovery.

Content

Through a logical series of presentations both from the participants and the lecturer (flipped classroom format, oral presentations, workshops) on the making of an innovative medicine, the entire and complex process starting from the therapeutic target identification up until the clinical development and use in clinical practice of a new molecular entity (NME) will be addressed and discussed.

 

The course is divided in eleven sections of each 2 periods of 45 minutes and sections 12 & 13 of 4 periods of 45 minutes :

Section 1          Scope of the course, general organization, case study

Section 2          Historical perspective: the modern pharmacy

Section 3          Introduction to translational research: crossing the bridge

Section 4-5      Therapeutic target identification I & II

Section 6          Structure based drug design, medicinal chemistry, low/high throughput screening assays, multiple parallel parameters optimization MDO

Section 7          Therapeutic peptides and biologicals: today's - tomorrow's pharmacy NBEs

Section 8          Personalized Healthcare (PHC) precision medicine

Section 9          Pharmacogenetic polymorphisms, Pharmacogenomics

Section 10        In vivo pharmacology, investigative toxicology

Section 11        Clinical research, phase 0, phase I, II, III, IV // Intellectual property, integrity in research, my genome vs our genomes

Section 12         Health Hackathon - Hacking medicine I

Section 13         Health Hackathon - Hacking medicine II

 

Minimum 10 participants

Maximum 25 participants

Keywords

Translational biomedical research/Drug discovery

Learning Prerequisites

Required courses

Basic knowledge in Molecular Biology, Chemistry, Cellular Signaling, Pharmacology

Resources

Bibliography

"A prescription for change : the looming crisis in drug development" Pr M. Kinch UNC Press(2017) ISBN 978-1-4696-3062-5

« Histoire de la médecine » Jean Starobinsky  Editions BHMS ISBN 978-2-88955-041-8

« The emperor of all maladies" Siddhartha Mukherjee Scribnee Ed. ISBN 978-1-4391-0795-9

"Drug-drug interactions" Albert Li  Academic Press Ed. ISBN 0-12032944-1

Ressources en bibliothèque

Notes/Handbook

 

 

Moodle Link

Dans les plans d'études

  • Nombre de places: 25
  • Forme de l'examen: Exposé (session libre)
  • Matière examinée: The making of an innovative medicine
  • Cours: 14 Heure(s)
  • Exercices: 14 Heure(s)
  • Type: optionnel
  • Nombre de places: 25
  • Forme de l'examen: Exposé (session libre)
  • Matière examinée: The making of an innovative medicine
  • Cours: 14 Heure(s)
  • Exercices: 14 Heure(s)
  • Type: optionnel
  • Nombre de places: 25
  • Forme de l'examen: Exposé (session libre)
  • Matière examinée: The making of an innovative medicine
  • Cours: 14 Heure(s)
  • Exercices: 14 Heure(s)
  • Type: optionnel

Semaine de référence

Cours connexes

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