CH-438 / 3 credits

Teacher: Zhu Jieping

Language: English


Summary

Complex polycyclic natural products are chosen to illustrate the evolution of the state-of-the-art of the field, the interplay between strategy and new reactions as well as the importance of implementing multi-bond forming processes in a synthesis.

Content

Retro-synthesis and synthesis of different classes of natural products important for their structure and/or bioactivity.

Keywords

Retro-synthetic analysis, Synergism between strategy and new reactions, Domino reactions, multicomponent reactions, Oxidative coupling, Pattern Recognition, Hidden Symmetry, C-H Functionalization, Asymmetric organocatalysis

 

Learning Prerequisites

Recommended courses

General knowledge of organic reactions. Basic knowledge of retro-syntheis. EPFL lectures fonctions et réactions organiques I and II, synthèse asymétrique, target synthesis, structure and reactivity or equivalent courses.

Learning Outcomes

By the end of the course, the student must be able to:

  • Draw reaction mechanism
  • Analyze synthetic route
  • Elaborate synthetic scheme
  • Design synthetic strategy

Supervision

Office hours Yes
Assistants Yes
Forum Yes

In the programs

  • Semester: Fall
  • Exam form: Written (winter session)
  • Subject examined: Total synthesis of natural products
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Type: optional
  • Semester: Fall
  • Exam form: Written (winter session)
  • Subject examined: Total synthesis of natural products
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Type: optional
  • Exam form: Written (winter session)
  • Subject examined: Total synthesis of natural products
  • Lecture: 2 Hour(s) per week x 14 weeks
  • Type: optional

Reference week

Tuesday, 8h - 10h: Lecture ELG116

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